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Repurposing drug benefits



repurposing

A new strategy for finding new uses of an approved or investigational drug is called repurposing. It may increase the efficacy or reduce side effects of an original product. There are many benefits to repurposing a drug. Here are just some:

Drug repurposing allows for the discovery of new uses for already approved or investigated medicines.

This is a unique strategy for developing new uses for drugs. It also helps to accelerate research in an ever-expanding field. To develop new therapies is the greatest reward of drug research. This process is much more achievable than the time-consuming and costly process of de novo drug discovery. The medicines have already been approved so repurposing is much more likely. Although the required clinical trials may not be as extensive, petitioners still need to conduct a clinical trial to prove safety and efficacy in higher dosages than the approved dose.

Repurposing is the process of repositioning drugs, reprofiling them, and salvaging them. This approach involves the integration of many disciplines: basic sciences, medicine, clinical research and medicine. An example is the creation of an Experimental Drug Network by academic units not supported by large foundations. This network would offer non-competitive advice for pharmaceutical companies. This network could be built around CTSA. This would enable these academic units access to the highly skilled work-force in the pharmaceutical industry.

It reduces mortality and morbidity

In cancer, repurposing is used to treat patients with cancer that do not respond to current treatments. A better treatment option than traditional cancer treatments is possible by using an off-patent medication. This is particularly true for rare and advanced cancers. They account for 20% to 20% of all new European cancer cases. In the past, repurposing was based on an ad-hoc discovery process. However, today, data-driven systematic approaches are being used to find new drugs and compounds. Many repurposing techniques incorporate computation, including Big Data or artificial intelligence.

It is highly efficient to repurpose existing drugs to treat your cancer. It also helps to identify new uses that are not possible with drugs that are well-known. Numerous drugs for different conditions have been successfully repurposed. You can repurpose drugs for different diseases at any stage of drug discovery, but it's most effective when the drug has been approved for another indication.

It improves efficacy

Repurposing drugs can be described as the repurposing of an old drug or a failed drug into a brand new indication. Now drugs are recognized to have a gene signature that provides insight into the molecular function. These information are the basis of new indications to repurpose drugs. This may allow for faster production of evidence. The preclinical phase includes animal models and safety testing. Then comes the clinical program, followed closely by approval.

Many benefits can be gained from repurposing drugs. It is possible to accelerate traditional drug discovery, find new clinical uses for an already existing drug, and lower the cost of drug development. It relies on molecular pathways that are common in many diseases. It is possible to improve a drug's effectiveness in one application by repurposing the drug for another purpose. But it also increases the computational complexity, which means it requires more time and computational power.

Side effects are reduced

Repurposing an existing drug has many advantages, including cost-effectiveness as well as time savings. Although past clinical and preclinical trials aren't always reliable, they can focus on different aspects the drug's mechanism. Furthermore, the process of developing a new drug can involve repeated steps, resulting in new-product approval with all of the associated costs and risks. This article examines the logic of drug repurposing. It also discusses various approaches to repurposing.

Repurposing is classified under several different categories. These include "off-label," "on-label", or repositioning as a clinical trial. A drug can be used by physicians for an indication that isn't listed on the label. However, many scientific societies and regulatory agencies are against this use. Moreover, the effectiveness and safety of a drug for an off-label indication may not be well-established. To get approval for a new indication requires significant investment. A patent is also required to guarantee a return.


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Repurposing drug benefits